![]() ![]() Warfarin antifungal agents drug interaction. This product contains nystatin, an anti-fungal drug that works by stopping the growth of fungus. Nystatin appears unlikely to interact with warfarin. This medication is used to treat fungal skin infections. Miconazole oral gel can clearly interact with warfarin to cause derangement of anticoagulation. Miconazole and nystatin used as topical antifungal drugs do not interact equally strongly with warfarin. No postulated mechanism of interaction, no additional published reported cases and no supportive data from adverse drug reports were identified which would corroborate the case for a significant interaction between nystatin and warfarin. There is strong evidence to support the derangement of warfarin anticoagulation by miconazole oral gel in all areas of evidence studied. ![]() (30 mL), each with an elongated tip for easy application and in. Dermalone Ointment is supplied in tubes of 1/4 fl. This study evaluates the evidence.Įvidence from the pharmacology literature, the medical literature and the 'yellow card' adverse drug reaction surveillance reports was analysed regarding possible interactions of nystatin and miconazole with warfarin. Dermalone Ointment is a combination of nystatin, neomycin sulfate, thiostrepton and triamcinolone acetonide in a non-irritating vehicle, a polyethylene and mineral oil gel base. If confirmed, this finding has significant implications for clinical practice. Oral or parenteral use of corticosteroids (depending on dose, duration of use, and specific steroid) may result in inhibition of endogenous steroid production following drug withdrawal.A retrospective case series published in 2012 concluded that miconazole and nystatin used as topical antifungal drugs appear to interact equally strongly with warfarin. Do not use if pus is present since the drug may allow the infection to spread. If redness, irritation, or swelling persists or increases, discontinue use. Therefore, an animal receiving Animax Ointment therapy should be observed closely for signs such as polydipsia, polyuria, and increased weight gain.Īnimax Ointment is not generally recommended for the treatment of deep or puncture wounds or serious burns. There is some evidence that corticosteroids can be absorbed after topical application and cause systemic effects. Derma-Vet Ointment combines nystatin, neomycin sulfate, thiostrepton and triamcinolone in a non-irritating, soothing mineral base. The occurrence of systemic reactions is rarely a problem with topical administration. Cutaneous reactions attributable to its use have been extremely rare. Parenteral antibiotic therapy is indicated in these infections.Īnimax Ointment (Nystatin-Neomycin Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment) has been extremely well tolerated. Together they provide comprehensive therapy against those organisms responsible for most superficial bacterial infections.Īnimax Ointment is not intended for the treatment of deep abscesses or deep-seated infections such as inflammation of the lymphatic vessels. Thiostrepton has a high order of activity against gram-positive organisms, including many which are resistant to other antibiotics neomycin exerts antimicrobial action against a wide range of gram-positive and gram-negative bacteria. No appreciable activity is exhibited against bacteria. Nystatin is fungistatic in vitro against a variety of yeast and yeast-like fungi including many fungi pathogenic to animals. Nystatin is the first well-tolerated antifungal antibiotic of dependable efficacy for the treatment of cutaneous infections caused by Candida albicans (Monilia). Inflammation, edema, and pruritis promptly subside, and lesions are permitted to heal. Triamcinolone acetonide is a potent synthetic corticosteroid providing rapid and prolonged symptomatic relief on topical administration. ACTIONS: By virtue of its four active ingredients, Animax Ointment provides four basic therapeutic effects: anti-inflammatory, antipruritic, antifungal and antibacterial. ![]()
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